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Comments Off on Holiday Closure Notice: Dec 24, 2018 through Jan 1, 2019

BRL will be closed for the Holidays: December 24 through January 1.→ Read more

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In:News

Comments Off on The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [18F]FDDNP PET

Caution is warranted when in vitro results of biomarkers labeled with tritium were perfunctorily used to criticize in vivo data and conclusions derived with the same tracers labeled with positron emitters and positron emission tomography (PET).→ Read more

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In:News

Comments Off on The neural response properties and cortical organization of a rapidly adapting muscle sensory group response that overlaps with the frequencies that elicit the kinesthetic illusion.

Kinesthesia is the sense of limb movement. It is fundamental to efficient motor control, yet its neurophysiological components remain poorly understood.→ Read more

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In:News

Comments Off on Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

Acetate supplementation increases brain acetyl-CoA metabolism, alters histone and non-histone protein acetylation, increases brain energy reserves, and is anti-inflammatory and neuroprotective in rat models of neuroinflammation and neuroborreliosis.→ Read more

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In:News

Comments Off on Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine

Compared with men, women show enhanced responses to drugs of abuse, and consequently are thought to be more vulnerable to addiction. The ovarian hormone estradiol has emerged as a key facilitator in the heightened development of addiction in females.→ Read more

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In:News

Comments Off on Emergent Global Contractile Force in Cardiac Tissues

The heart is a complex organ whose structure and function are intricately linked at multiple length scales. Although several advancements have been achieved in the field of cardiac tissue engineering, current in vitro cardiac tissues do not fully replicate the structure or function necessary for effective cardiac therapy and cardiotoxicity→ Read more

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In:News

Comments Off on Brain α7 nicotinic acetylcholine receptors in MPTP-lesioned monkeys and parkinsonian patients

L-DOPA-induced dyskinesias (LID) appear in the majority of Parkinson’s disease (PD) patients. Nicotinic acetylcholine (nACh) receptor-mediated signaling has been implicated in PD and LID and modulation of brain α7 nACh receptors might be a potential therapeutic target for PD.→ Read more

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In:News

Comments Off on Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures

Stem cell-based therapy of retinal degenerative conditions is a promising modality to treat blindness, but requires new strategies to improve the number of functionally integrating cells.→ Read more

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In:News

Comments Off on Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications

L-DOPA-induced dyskinesias (LID) are abnormal involuntary movements limiting the chronic use of L-DOPA, the main pharmacological treatment of Parkinson’s disease.→ Read more

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In:News

Comments Off on Cell proliferation is reduced in the hippocampus in schizophrenia

Objective: The molecular and cellular basis of structural and functional abnormalities of the hippocampus found in schizophrenia is currently unclear.→ Read more