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Comments Off on Emergent Global Contractile Force in Cardiac Tissues

The heart is a complex organ whose structure and function are intricately linked at multiple length scales. Although several advancements have been achieved in the field of cardiac tissue engineering, current in vitro cardiac tissues do not fully replicate the structure or function necessary for effective cardiac therapy and cardiotoxicity→ Read more

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Comments Off on Brain α7 nicotinic acetylcholine receptors in MPTP-lesioned monkeys and parkinsonian patients

L-DOPA-induced dyskinesias (LID) appear in the majority of Parkinson’s disease (PD) patients. Nicotinic acetylcholine (nACh) receptor-mediated signaling has been implicated in PD and LID and modulation of brain α7 nACh receptors might be a potential therapeutic target for PD.→ Read more

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Comments Off on Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures

Stem cell-based therapy of retinal degenerative conditions is a promising modality to treat blindness, but requires new strategies to improve the number of functionally integrating cells.→ Read more

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Comments Off on Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications

L-DOPA-induced dyskinesias (LID) are abnormal involuntary movements limiting the chronic use of L-DOPA, the main pharmacological treatment of Parkinson’s disease.→ Read more

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Comments Off on Cell proliferation is reduced in the hippocampus in schizophrenia

Objective: The molecular and cellular basis of structural and functional abnormalities of the hippocampus found in schizophrenia is currently unclear.→ Read more

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Comments Off on Impact of immersion oils and mounting media on the confocal imaging of dendritic spines

Structural plasticity, such as changes in dendritic spine morphology and density, reflect changes in synaptic connectivity and circuitry. Procedural variables used in different methods for labeling dendritic spines have been quantitatively evaluated for their impact on the ability to resolve individual spines in confocal microscopic analyses. In contrast, there have→ Read more

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