Author Archives: Brain Research Lab

Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

Acetate supplementation increases brain acetyl-CoA metabolism, alters histone and non-histone protein acetylation, increases brain energy [...]

Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine

Compared with men, women show enhanced responses to drugs of abuse, and consequently are thought [...]

Emergent Global Contractile Force in Cardiac Tissues

The heart is a complex organ whose structure and function are intricately linked at multiple [...]

Brain α7 nicotinic acetylcholine receptors in MPTP-lesioned monkeys and parkinsonian patients

L-DOPA-induced dyskinesias (LID) appear in the majority of Parkinson’s disease (PD) patients. Nicotinic acetylcholine (nACh) [...]

Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures

Stem cell-based therapy of retinal degenerative conditions is a promising modality to treat blindness, but [...]

Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications

L-DOPA-induced dyskinesias (LID) are abnormal involuntary movements limiting the chronic use of L-DOPA, the main [...]

Cell proliferation is reduced in the hippocampus in schizophrenia

Objective: The molecular and cellular basis of structural and functional abnormalities of the hippocampus found [...]

Impact of immersion oils and mounting media on the confocal imaging of dendritic spines

Structural plasticity, such as changes in dendritic spine morphology and density, reflect changes in synaptic [...]

Stereological Study of Amygdala Glial Populations in Adolescents and Adults with Autism Spectrum Disorder

The amygdala undergoes aberrant development in autism spectrum disorder (ASD). We previously found that there [...]

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

Sporadic Alzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by progressive neurodegeneration. Decreased [...]