Author Archives: Brain Research Lab

Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys

In Parkinson's disease (PD) and l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesias (LIDs), overactivity of brain glutamate neurotransmission is [...]

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice.

Decreased brain insulin signaling has been found recently in Alzheimer's disease (AD). Intranasal administration of [...]

Cortical innervation of the hypoglossal nucleus in the non-human primate (Macaca mulatta)

The corticobulbar projection to the hypoglossal nucleus was studied from the frontal, parietal, cingulate and [...]

Overexpression of Diacylglycerol Kinase η Enhances Gαq-Coupled G Protein–Coupled Receptor Signaling

Multiple genome-wide association studies have linked diacylglycerol kinase η(DGKη) to bipolar disorder (BPD).

Induction of cobalt accumulation by excitatory amino acids within neurons of the hippocampal slice. May 1992

Multiple genome-wide association studies have linked diacylglycerol kinase η(DGKη) to bipolar disorder (BPD).

Postmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstruction

Modern scientific knowledge of how memory functions are organized in the human brain originated from [...]

Long-term treatment with l-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys

Brain glutamate overactivity is well documented in Parkinson's disease (PD) and antiglutamatergic drugs decrease L-3,4-dihydroxyphenylalanine [...]

Chronic wheel running affects cocaine-induced c-Fos expression in brain reward areas in rats

Emerging evidence from human and animal studies suggests that exercise is a highly effective treatment [...]

Brain Imaging Differences in Infants at Genetic Risk for Alzheimer’s

Using a special MRI technique designed for studies of sleeping infants, researchers at Brown University [...]

60 Years Of Looking At The Human Brain And Not Done Yet

A generation of baby boomers has watched their parents live to an unprecedented age and [...]